Scottish Fold genetics
The folded ear of the Scottish Fold is produced by a dominant mutation in the TRPV4 gene (Fd). Because the same mutation affects cartilage development throughout the body, every Fold carries a degree of risk for a condition called osteochondrodysplasia (SFOCD).
Two important facts shape what responsible breeding looks like:
- The condition is dose-dependent. Homozygous cats (Fd/Fd) develop severe, painful skeletal deformity. Heterozygous cats (Fd/fd) have markedly lower expression.
- Heterozygous cats are produced only by pairing a folded-ear cat with a straight-eared cat — what we call Fold × Straight pairing.
Our breeding protocol
- We never breed two folded-ear cats together. Every Aurelian litter is a Fold × Straight pairing.
- Both parents are DNA-tested for PKD and screened for HCM by echocardiogram annually.
- Breeding cats receive annual orthopedic radiographs of the tail base, tarsal joints, and metatarsal region.
- Any kitten showing radiographic or behavioral evidence of skeletal abnormality is placed as a non-breeding companion with full disclosure and veterinary follow-up paid by the cattery.
Veterinary partnerships
Our practice is co-managed with Dr. Helena Whitfield, DVM, DACVS-SA (orthopedic surgery), and Dr. Marcus Lee, DVM, DACVIM (feline medicine). Both consult on every litter and provide independent oversight of our screening program.
Vaccination & nutrition
Kittens receive their first FVRCP vaccination at six weeks and a booster at nine weeks. Rabies is administered at sixteen weeks per AAFP guidelines. Kittens are fed a mother-and-babycat formula from weaning, with a transition to a joint-supportive adult formula at six months.
Ethical commitments
- Two litters per queen per year, maximum. Retirement at age five into a vetted family home.
- No sale to brokers, pet stores, or homes intending to declaw.
- Kittens placed no earlier than 12 weeks of age.
- Lifetime contractual right of return — we will always rehome rather than allow surrender to a shelter.
References & further reading
Every claim on this page is drawn from peer-reviewed veterinary literature, breed-registry standards, and cardiology/orthopedic specialty guidelines. The primary sources we rely on:
- TICA — Scottish Fold Breed Standard (registry standard, pairing rules, disqualifications).
- CFA — Scottish Fold Breed Standard (structure, coat, ear-fold grading, allowable outcrosses).
- Malik R., Allan G. S., Howlett C. R., et al. "Osteochondrodysplasia in Scottish Fold cats." Australian Veterinary Journal, 1999;77(2):85–92. — the foundational clinical and radiographic description of SFOCD.
- Takanosu M., Takanosu T., Suzuki H., Suzuki K. "Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats." Journal of Small Animal Practice, 2008;49(4):197–199.
- Gandolfi B., et al. "A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish Fold cats." Osteoarthritis and Cartilage, 2016;24(8):1441–1450. — identifies the causative gene.
- British Veterinary Association — Position on the breeding of Scottish Fold cats.
- International Cat Care — Scottish Fold Disease (Osteochondrodysplasia).
- AAFP / AAHA Feline Vaccination Guidelines — the FVRCP and rabies schedule cited above.
- UC Davis Veterinary Genetics Laboratory — Feline PKD1 DNA test (the PKD panel we use on every breeding cat).
Full PDFs of the peer-reviewed papers above are available on request for families researching the breed.
Page last reviewed: June 20, 2026 · Reviewed by Margaret Aurelian and Dr. Helena Whitfield, DVM, DACVS-SA